Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity Without Severe Toxicity

The majority of chimeric antigen receptor (CAR) T cell research has focused on attacking cancer cells. Here we show that targeting the tumor-promoting, non-transformed stromal cells using CAR T cells may offer several advantages. We developed a retroviral CAR construct specific for the mouse fibrobl...

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Detalhes bibliográficos
Main Authors: Wang, Liang-Chuan S, Lo, Albert, Scholler, John, Sun, Jing, Majumdar, Rajrupa S, Kapoor, Veena, Antzis, Michael, Cotner, Cody E., Johnson, Laura A, Durham, Amy C, Solomides, Charalambos C., June, Carl H, Puré, Ellen, Albelda, Steven M
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007316/
https://ncbi.nlm.nih.gov/pubmed/24778279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-13-0027
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