An improved LC-MS/MS method for quantitative determination of ilaprazole and its metabolites in human plasma and its application to a pharmacokinetic study

AIM: To improve and validate an analytical method based on liquid chromatography and electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) for the quantitative measurement of ilaprazole and its two metablites in human plasma. METHODS: Separation of analytes and the internal standard (IS),...

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Dettagli Bibliografici
Autori principali: Zhou, Gan, Tan, Zhi-rong, Zhang, Wei, Ou-Yang, Dong-sheng, Chen, Yao, Guo, Dong, Liu, Ying-zi, Fan, Lan, Deng, Han-wu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2009
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007177/
https://ncbi.nlm.nih.gov/pubmed/19701234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2009.120
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