Ribonucleotide reductase activity is regulated by proliferating cell nuclear antigen (PCNA)

Synthesis of dNTPs is required for both DNA replication and DNA repair and is catalyzed by ribonucleotide reductases (RNR), which convert ribonucleotides to their deoxy forms [1, 2]. Maintaining the correct levels of dNTPs for DNA synthesis is important for minimising the mutation rate [3-7], and th...

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Main Authors: Salguero, Israel, Guarino, Estrella, Shepherd, Marianne, Deegan, Tom, Havens, Courtney G., MacNeill, Stuart A., Walter, Johannes C., Kearsey, Stephen E.
格式: Artigo
語言:Inglês
出版: 2012
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007158/
https://ncbi.nlm.nih.gov/pubmed/22464192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.02.070
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