Nociceptin/Orphanin FQ Suppresses Adaptive Immune Responses in Vivo and at Picomolar Levels in Vitro

Nociceptin/orphanin FQ (N/OFQ), added in vitro to murine spleen cells in the picomolar range, suppressed antibody formation to sheep red blood cells in a primary and a secondary plaque-forming cell (PFC) assay. The activity of the peptide was maximal at 10(−12) M, with an asymmetric U-shaped dose re...

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Bibliografski detalji
Glavni autori: Anton, Benito, Calva, Juan C., Acevedo, Rodolfo, Salazar, Alberto, Matus, Maura, Flores, Anabel, Martinez, Martin, Adler, Martin W., Gaughan, John P., Eisenstein, Toby K.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007060/
https://ncbi.nlm.nih.gov/pubmed/20119853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-010-9190-2
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