Mitochondria–Nucleus Shuttling FK506-Binding Protein 51 Interacts with TRAF Proteins and Facilitates the RIG-I-Like Receptor-Mediated Expression of Type I IFN

Virus-derived double-stranded RNAs (dsRNAs) are sensed in the cytosol by retinoic acid-inducible gene (RIG)-I-like receptors (RLRs). These induce the expression of type I IFN and proinflammatory cytokines through signaling pathways mediated by the mitochondrial antiviral signaling (MAVS) protein. TN...

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Hauptverfasser: Akiyama, Taishin, Shiraishi, Takuma, Qin, Junwen, Konno, Hiroyasu, Akiyama, Nobuko, Shinzawa, Miho, Miyauchi, Maki, Takizawa, Nobukazu, Yanai, Hiromi, Ohashi, Hiroyuki, Miyamoto-Sato, Etsuko, Yanagawa, Hiroshi, Yong, Weidong, Shou, Weinian, Inoue, Jun-ichiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006813/
https://ncbi.nlm.nih.gov/pubmed/24788966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095992
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