Antibiotic-free segregational plasmid stabilization in Escherichia coli owing to the knockout of triosephosphate isomerase (tpiA)

BACKGROUND: Segregational stability of plasmids is of major concern for recombinant bacterial production strains. One of the best strategies to counteract plasmid loss is the use of auxotrophic mutants which are complemented with the lacking gene along with the product-relevant ones. However, these...

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Detaylı Bibliyografya
Asıl Yazarlar: Velur Selvamani, Ram Shankar, Telaar, Maurice, Friehs, Karl, Flaschel, Erwin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2014
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006690/
https://ncbi.nlm.nih.gov/pubmed/24745552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-13-58
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