Sequencing Antibody Repertoires Provides Evidence for Original Antigenic Sin Shaping the Antibody Response to Influenza Vaccination

We used a DNA barcoding method to enable high-throughput sequencing of the cognate heavy- and light-chain pairs of expressed antibodies. We used this approach to elucidate the plasmablast antibody response to influenza vaccination. We show that >75% of the rationally selected plasmablast antibodi...

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Huvudupphovsmän: Tan, Yann-Chong, Scalfone, Lisa K., Kongpachith, Sarah, Ju, Chia-Hsin, Cai, Xiaoyong, Lindstrom, Tamsin M., Sokolove, Jeremy, Robinson, William H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006370/
https://ncbi.nlm.nih.gov/pubmed/24525048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2013.12.008
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