TGFβ2 dictates disseminated tumour cell fate in target organs through TGFβ-RIII and p38α/β signalling

In patients non-proliferative disseminated tumour cells (DTCs) can persist in the bone marrow (BM) while other organs (i.e. lung) present growing metastasis. This suggested that the BM might be a metastasis “restrictive soil” by encoding dormancy-inducing cues in DTCs. Here we show in a HNSCC model...

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Main Authors: Bragado, Paloma, Estrada, Yeriel, Parikh, Falguni, Krause, Sarah, Capobianco, Carla, Farina, Hernan G., Schewe, Denis M, Aguirre-Ghiso, Julio A.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006312/
https://ncbi.nlm.nih.gov/pubmed/24161934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2861
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