NR2F1 controls tumor cell dormancy via SOX9 and RARβ driven quiescence programs

Metastases can originate from disseminated tumor cells (DTCs), which may be dormant for years before reactivation. Here we find that the orphan nuclear receptor NR2F1 is epigenetically upregulated in experimental HNSCC dormancy models and in DTCs from prostate cancer patients carrying dormant diseas...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Sosa, Maria Soledad, Parikh, Falguni, Maia, Alexandre Gaspar, Estrada, Yeriel, Bosch, Almudena, Bragado, Paloma, Ekpin, Esther, George, Ajish, Zheng, Yang, Lam, Hung-Ming, Morrissey, Colm, Chung, Chi-Yeh, Farias, Eduardo F., Bernstein, Emily, Aguirre-Ghiso, Julio A.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313575/
https://ncbi.nlm.nih.gov/pubmed/25636082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7170
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