Novel Inhalational Murine Model of Invasive Pulmonary Aspergillosis

We developed a novel model of invasive aspergillosis (IA) that recapitulates human disease. Mice were immunosuppressed with cyclophosphamide and cortisone acetate and then infected in an aerosol chamber. This procedure reproducibly delivered 1 × 10(3) to 3 × 10(3) conidia to the lungs. Lethal pulmon...

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Bibliografiske detaljer
Main Authors: Sheppard, Donald C., Rieg, Gunter, Chiang, Lisa Y., Filler, Scott G., Edwards, John E., Ibrahim, Ashraf S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC400587/
https://ncbi.nlm.nih.gov/pubmed/15105158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.5.1908-1911.2004
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