In Vivo Efficacy and Pharmacokinetics of AC98-6446, a Novel Cyclic Glycopeptide, in Experimental Infection Models

AC98-6446 is a novel semisynthetic derivative of a natural product related to the mannopeptimycins produced by Streptomyces hygroscopicus. Naturally occurring esterified mannopeptimycins exhibited excellent in vitro activity but only moderate in vivo efficacy against staphylococcal infection. The in...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Weiss, William J., Murphy, Timothy, Lenoy, Eileen, Young, Mairead
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2004
Témata:	Experimental Therapeutics
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC400572/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15105124/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.5.1708-1712.2004
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