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Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors

Ribosome biogenesis is a key process for maintaining protein synthetic capacity in dividing or growing cells, and requires coordinated production of ribosomal proteins and ribosomal RNA (rRNA), including the processing of the latter. Signalling through mammalian target of rapamycin complex 1 (mTORC1...

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Detalhes bibliográficos
Main Authors: Liu, Rui, Iadevaia, Valentina, Averous, Julien, Taylor, Peter M., Zhang, Ze, Proud, Christopher G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005692/
https://ncbi.nlm.nih.gov/pubmed/24526220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku130
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