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Ribonuclease L and metal-ion–independent endoribonuclease cleavage sites in host and viral RNAs

Ribonuclease L (RNase L) is a metal-ion–independent endoribonuclease associated with antiviral and antibacterial defense, cancer and lifespan. Despite the biological significance of RNase L, the RNAs cleaved by this enzyme are poorly defined. In this study, we used deep sequencing methods to reveal...

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Main Authors: Cooper, Daphne A., Jha, Babal K., Silverman, Robert H., Hesselberth, Jay R., Barton, David J.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2014
主題:
RNA
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005677/
https://ncbi.nlm.nih.gov/pubmed/24500209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku118
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