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Ribonuclease L and metal-ion–independent endoribonuclease cleavage sites in host and viral RNAs

Ribonuclease L (RNase L) is a metal-ion–independent endoribonuclease associated with antiviral and antibacterial defense, cancer and lifespan. Despite the biological significance of RNase L, the RNAs cleaved by this enzyme are poorly defined. In this study, we used deep sequencing methods to reveal...

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Detalhes bibliográficos
Main Authors: Cooper, Daphne A., Jha, Babal K., Silverman, Robert H., Hesselberth, Jay R., Barton, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005677/
https://ncbi.nlm.nih.gov/pubmed/24500209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku118
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