The Trypanocide Diminazene Aceturate Is Accumulated Predominantly through the TbAT1 Purine Transporter: Additional Insights on Diamidine Resistance in African Trypanosomes

Resistance to diminazene aceturate (Berenil) is a severe problem in the control of African trypanosomiasis in domestic animals. It has been speculated that resistance may be the result of reduced diminazene uptake by the parasite. We describe here the mechanisms by which [(3)H]diminazene is transpor...

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מידע ביבליוגרפי
Main Authors: de Koning, Harry P., Anderson, Laura F., Stewart, Mhairi, Burchmore, Richard J. S., Wallace, Lynsey J. M., Barrett, Michael P.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2004
נושאים:
Mechanisms of Resistance
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC400564/
https://ncbi.nlm.nih.gov/pubmed/15105099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.5.1515-1519.2004
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