Interactions between the non-seed region of siRNA and RNA-binding RLC/RISC proteins, Ago and TRBP, in mammalian cells

Small interfering RNA (siRNA)-based RNA interference (RNAi) is widely used for target gene silencing in various organisms. We previously showed that 8-nt-long 5′ proximal nucleotides, which include seed sequence (positions 2–8 from the 5′ end of guide strand), and the complementary sequence of the p...

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Hlavní autoři: Takahashi, Tomoko, Zenno, Shuhei, Ishibashi, Osamu, Takizawa, Toshihiro, Saigo, Kaoru, Ui-Tei, Kumiko
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005638/
https://ncbi.nlm.nih.gov/pubmed/24561616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku153
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