MLL-rearranged acute lymphoblastic leukaemia stem cell interactions with bone marrow stroma promote survival and therapeutic resistance that can be overcome with CXCR4 antagonism

Infants with MLL-rearranged (MLL-R) acute lymphoblastic leukaemia (ALL) have a dismal prognosis. While most patients achieve remission, approximately half of patients recur with a short latency to relapse. This suggests that chemotherapy-resistant leukaemia stem cells (LSCs) survive and can recapitu...

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Autores principales: Sison, Edward Allan R., Rau, Rachel E., McIntyre, Emily, Li, Li, Small, Donald, Brown, Patrick
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005340/
https://ncbi.nlm.nih.gov/pubmed/23294096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.12205
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