Syndecan-4 Knockout Leads to Reduced Extracellular Transglutaminase-2 and Protects against Tubulointerstitial Fibrosis

Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. The interaction of TG2 with the heparan sulfate proteoglycan syndecan-4 (Sdc4) regulates the cell surface trafficking, localization, and activity of TG2 in vitro but remains unstudied...

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Main Authors: Scarpellini, Alessandra, Huang, Linghong, Burhan, Izhar, Schroeder, Nina, Funck, Muriel, Johnson, Timothy S., Verderio, Elisabetta A.M.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2014
Teme:
Basic Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005302/
https://ncbi.nlm.nih.gov/pubmed/24357671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013050563
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