Proteomic Profiling Reveals the Transglutaminase-2 Externalization Pathway in Kidneys after Unilateral Ureteric Obstruction

Increased export of transglutaminase-2 (TG2) by tubular epithelial cells (TECs) into the surrounding interstitium modifies the extracellular homeostatic balance, leading to fibrotic membrane expansion. Although silencing of extracellular TG2 ameliorates progressive kidney scarring in animal models o...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Am Soc Nephrol
Päätekijät: Furini, Giulia, Schroeder, Nina, Huang, Linghong, Boocock, David, Scarpellini, Alessandra, Coveney, Clare, Tonoli, Elisa, Ramaswamy, Raghavendran, Ball, Graham, Verderio, Claudia, Johnson, Timothy S., Verderio, Elisabetta A.M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Nephrology 2018
Aiheet:
Basic Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827594/
https://ncbi.nlm.nih.gov/pubmed/29382685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017050479
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