Proteomic Profiling Reveals the Transglutaminase-2 Externalization Pathway in Kidneys after Unilateral Ureteric Obstruction

Increased export of transglutaminase-2 (TG2) by tubular epithelial cells (TECs) into the surrounding interstitium modifies the extracellular homeostatic balance, leading to fibrotic membrane expansion. Although silencing of extracellular TG2 ameliorates progressive kidney scarring in animal models o...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Furini, Giulia, Schroeder, Nina, Huang, Linghong, Boocock, David, Scarpellini, Alessandra, Coveney, Clare, Tonoli, Elisa, Ramaswamy, Raghavendran, Ball, Graham, Verderio, Claudia, Johnson, Timothy S., Verderio, Elisabetta A.M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2018
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827594/
https://ncbi.nlm.nih.gov/pubmed/29382685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017050479
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