Mutant Selection Window in Levofloxacin and Moxifloxacin Treatments of Experimental Pneumococcal Pneumonia in a Rabbit Model of Human Therapy

For some pneumococci the fluoroquinolone MICs are low but the mutant prevention concentrations (MPCs) are high; this difference defines in vitro the mutant selection window (MSW). We investigated in vivo the bacterial reduction and the occurrence of resistant mutants with moxifloxacin (MFX; 400 mg o...

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Bibliografische gegevens
Hoofdauteurs: Croisier, Delphine, Etienne, Manuel, Bergoin, Emilie, Charles, Pierre-Emmanuel, Lequeu, Catherine, Piroth, Lionel, Portier, Henri, Chavanet, Pascal
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2004
Onderwerpen:
Experimental Therapeutics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC400524/
https://ncbi.nlm.nih.gov/pubmed/15105123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.5.1699-1707.2004
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