Development of a New Experimental Model of Penicillin-Resistant Streptococcus pneumoniae Pneumonia and Amoxicillin Treatment by Reproducing Human Pharmacokinetics

The increase of penicillin-resistant Streptococcus pneumoniae (PRSP) pneumonia results in a greater risk of antibiotic treatment failure. In vitro data are not sufficient predictors of clinical efficacy, and animal models may be insufficiently contributive, since they often use immunocompromised ani...

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Autori principali: Piroth, Lionel, Martin, Laurent, Coulon, Alexis, Lequeu, Catherine, Duong, Michel, Buisson, Marielle, Portier, Henri, Chavanet, Pascal
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 1999
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC89505/
https://ncbi.nlm.nih.gov/pubmed/10508029
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