Development of a New Experimental Model of Penicillin-Resistant Streptococcus pneumoniae Pneumonia and Amoxicillin Treatment by Reproducing Human Pharmacokinetics

The increase of penicillin-resistant Streptococcus pneumoniae (PRSP) pneumonia results in a greater risk of antibiotic treatment failure. In vitro data are not sufficient predictors of clinical efficacy, and animal models may be insufficiently contributive, since they often use immunocompromised ani...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Piroth, Lionel, Martin, Laurent, Coulon, Alexis, Lequeu, Catherine, Duong, Michel, Buisson, Marielle, Portier, Henri, Chavanet, Pascal
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1999
Soggetti:	Experimental Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89505/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10508029/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.10.2484
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