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CD133+ cells contribute to radioresistance via altered regulation of DNA repair genes in human lung cancer cells

BACKGROUND: Radioresistance in human tumors has been linked in part to a subset of cells termed cancer stem cells (CSCs). The prominin 1 (CD133) cell surface protein is proposed to be a marker enriching for CSCs. We explore the importance of DNA repair in contributing to radioresistance in CD133+ lu...

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Detalhes bibliográficos
Main Authors: Desai, Amar, Webb, Bryan, Gerson, Stanton L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004669/
https://ncbi.nlm.nih.gov/pubmed/24440048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.radonc.2013.10.040
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