Tyrosine 813 Is a Site of JAK2 Autophosphorylation Critical for Activation of JAK2 by SH2-Bβ

The tyrosine kinase Janus kinase 2 (JAK2) binds to the majority of the known members of the cytokine family of receptors. Ligand-receptor binding leads to activation of the associated JAK2 molecules, resulting in rapid autophosphorylation of multiple tyrosines within JAK2. Phosphotyrosines can then...

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Detalhes bibliográficos
Main Authors: Kurzer, Jason H., Argetsinger, Lawrence S., Zhou, Yong-Jie, Kouadio, Jean-Louis K., O'Shea, John J., Carter-Su, Christin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC400461/
https://ncbi.nlm.nih.gov/pubmed/15121872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.10.4557-4570.2004
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