Interleukin-17 Retinotoxicity Is Prevented by Gene Transfer of a Soluble Interleukin-17 Receptor Acting as a Cytokine Blocker: Implications for Age-Related Macular Degeneration

Age-related macular degeneration (AMD) is a common yet complex retinal degeneration that causes irreversible central blindness in the elderly. Pathology is widely believed to follow loss of retinal pigment epithelium (RPE) and photoreceptor degeneration. Here we report aberrant expression of interle...

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Main Authors: Ardeljan, Daniel, Wang, Yujuan, Park, Stanley, Shen, Defen, Chu, Xi Kathy, Yu, Cheng-Rong, Abu-Asab, Mones, Tuo, Jingsheng, Eberhart, Charles G., Olsen, Timothy W., Mullins, Robert F., White, Gary, Wadsworth, Sam, Scaria, Abraham, Chan, Chi-Chao
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004582/
https://ncbi.nlm.nih.gov/pubmed/24780906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095900
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