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Recoding the Genetic Code with Selenocysteine

Selenocysteine (Sec) is naturally incorporated into proteins by recoding the stop codon UGA. Sec is not hardwired to UGA, as we found the Sec insertion machinery to be able to site-specifically incorporate Sec directed by 58 of the 64 codons. For 15 sense codons, complete conversion of the codon mea...

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Bibliographic Details
Main Authors: Bröcker, Markus J., Ho, Joanne M. L., Church, George M., Söll, Dieter, Donoghue, Patrick O
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004526/
https://ncbi.nlm.nih.gov/pubmed/24511637
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