Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage

[Image: see text] Oligomers of the amyloid-β (Aβ) peptide have been implicated in the neurotoxicity associated with Alzheimer’s disease. We have used single-molecule techniques to examine quantitatively the cellular effects of adding well characterized Aβ oligomers to primary hippocampal cells and h...

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Bibliographic Details
Main Authors: Narayan, Priyanka, Holmström, Kira M., Kim, Dong-Hyun, Whitcomb, Daniel J., Wilson, Mark R., St. George-Hyslop, Peter, Wood, Nicholas W., Dobson, Christopher M., Cho, Kwangwook, Abramov, Andrey Y., Klenerman, David
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004235/
https://ncbi.nlm.nih.gov/pubmed/24717093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401606f
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