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The microtubule cytoskeleton is required for a G2 cell cycle delay in cancer cells lacking stathmin and p53

In several cancer cell lines, depleting the microtubule-destabilizing protein stathmin/oncoprotein18 leads to a G2 cell cycle delay and apoptosis. These phenotypes are observed only in synergy with low levels of p53, but the pathway(s) activated by stathmin depletion to delay the cell cycle are unkn...

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Detalhes bibliográficos
Main Authors: Carney, Bruce K., Caruso Silva, Victoria, Cassimeris, Lynne
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004097/
https://ncbi.nlm.nih.gov/pubmed/22407961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cm.21024
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