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The Catastrophe-promoting Activity of Ectopic Op18/Stathmin Is Required for Disruption of Mitotic Spindles But Not Interphase Microtubules

Oncoprotein18/stathmin (Op18) is a microtubule (MT) destabilizing protein that is inactivated during mitosis by phosphorylation at four Ser-residues. Op18 has at least two functions; the N-terminal region is required for catastrophe-promotion (i.e., transition from elongation to shortening), while t...

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Auteurs principaux: Holmfeldt, Per, Larsson, Niklas, Segerman, Bo, Howell, Bonnie, Morabito, Justin, Cassimeris, Lynne, Gullberg, Martin
Format: Artigo
Langue:Inglês
Publié: The American Society for Cell Biology 2001
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC30569/
https://ncbi.nlm.nih.gov/pubmed/11160824
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