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APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition
Long INterspersed Element-1 (LINE-1 or L1) retrotransposition poses a mutagenic threat to human genomes. Human cells have therefore evolved strategies to regulate L1 retrotransposition. The APOBEC3 (A3) gene family consists of seven enzymes that catalyze deamination of cytidine nucleotides to uridin...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4003774/ https://ncbi.nlm.nih.gov/pubmed/24843014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02008 |
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