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APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition

Long INterspersed Element-1 (LINE-1 or L1) retrotransposition poses a mutagenic threat to human genomes. Human cells have therefore evolved strategies to regulate L1 retrotransposition. The APOBEC3 (A3) gene family consists of seven enzymes that catalyze deamination of cytidine nucleotides to uridin...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Richardson, Sandra R, Narvaiza, Iñigo, Planegger, Randy A, Weitzman, Matthew D, Moran, John V
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003774/
https://ncbi.nlm.nih.gov/pubmed/24843014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02008
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