Biodistribution of AAV8 Vectors Expressing Human Low-Density Lipoprotein Receptor in a Mouse Model of Homozygous Familial Hypercholesterolemia

Recombinant adeno-associated viral vectors based on serotype 8 (AAV8) transduce liver with superior tropism following intravenous (IV) administration. Previous studies conducted by our lab demonstrated that AAV8-mediated transfer of the human low-density lipoprotein receptor (LDLR) gene driven by a...

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Detalhes bibliográficos
Main Authors: Chen, Shu-Jen, Sanmiguel, Julio, Lock, Martin, McMenamin, Deirdre, Draper, Christine, Limberis, Maria P., Kassim, Sadik H., Somanathan, Suryanarayan, Bell, Peter, Johnston, Julie C., Rader, Daniel J., Wilson, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Pre-Clinical Safety Trials
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003465/
https://ncbi.nlm.nih.gov/pubmed/24070336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/humc.2013.082
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