Involvement of cytochrome P450 3A4 and P-glycoprotein in first-pass intestinal extraction of omeprazole in rabbits

AIM: To quantitatively evaluate in vivo first-pass intestinal extraction of omeprazole and to investigate the possible involvement of cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) in this process in rabbits. METHODS: Pharmacokinetic parameters were examined after intraduodenal (id), intrapo...

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Autores principales: Fang, Hai-ming, Xu, Jian-ming, Mei, Qiao, Diao, Lei, Chen, Mo-li, Jin, Juan, Xu, Xin-hua
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2009
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003004/
https://ncbi.nlm.nih.gov/pubmed/19820718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2009.142
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