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Direct regulation of interleukin-6 expression by Notch signaling in macrophages
Interleukin-6 (IL-6) is a pleiotropic, pro-inflammatory cytokine produced by various types of cells, including macrophages. Within the IL-6 gene promoter region, the signature binding motif of CBF1/Su(H)/Lag-1 (CSL), a key DNA-binding protein in the Notch signaling pathway, was identified and found...
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| Glavni autori: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4002803/ https://ncbi.nlm.nih.gov/pubmed/21983868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2011.36 |
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