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Direct regulation of interleukin-6 expression by Notch signaling in macrophages

Interleukin-6 (IL-6) is a pleiotropic, pro-inflammatory cytokine produced by various types of cells, including macrophages. Within the IL-6 gene promoter region, the signature binding motif of CBF1/Su(H)/Lag-1 (CSL), a key DNA-binding protein in the Notch signaling pathway, was identified and found...

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Detalhes bibliográficos
Main Authors: Wongchana, Wipawee, Palaga, Tanapat
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002803/
https://ncbi.nlm.nih.gov/pubmed/21983868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2011.36
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