Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain β-amyloid through PPARγ activation

AIM: To examine the effects of pioglitazone, a PPARγ agonist, on memory performance and brain amyloidogenesis in streptozotocin (STZ)-induced diabetic mice. METHODS: ICR male mice were injected with STZ (150 mg/kg, iv) to induce experimental diabetes. Pioglitazone (9 and 18 mg·kg(-1)·d(-1), po) was...

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Hlavní autoři: Liu, Li-ping, Yan, Tian-hua, Jiang, Li-ying, Hu, Wei, Hu, Meng, Wang, Chao, Zhang, Qian, Long, Yan, Wang, Jiang-qing, Li, Yong-qi, Hu, Mei, Hong, Hao
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002797/
https://ncbi.nlm.nih.gov/pubmed/23524568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.11
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