Platinum-(IV)-derivative satraplatin induced G(2)/M cell cycle perturbation via p53-p21(waf1/cip1)-independent pathway in human colorectal cancer cells

AIM: Platinum-(IV)-derivative satraplatin represents a new generation of orally available anti-cancer drugs that are under development for the treatment of several cancers. Understanding the mechanisms of cell cycle modulation and apoptosis is necessary to define the mode of action of satraplatin. I...

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Autori principali: Kalimutho, Murugan, Minutolo, Antonella, Grelli, Sandro, Federici, Giorgio, Bernardini, Sergio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002728/
https://ncbi.nlm.nih.gov/pubmed/21927014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.107
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