Platinum-(IV)-derivative satraplatin induced G(2)/M cell cycle perturbation via p53-p21(waf1/cip1)-independent pathway in human colorectal cancer cells

AIM: Platinum-(IV)-derivative satraplatin represents a new generation of orally available anti-cancer drugs that are under development for the treatment of several cancers. Understanding the mechanisms of cell cycle modulation and apoptosis is necessary to define the mode of action of satraplatin. I...

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Bibliografiske detaljer
Main Authors: Kalimutho, Murugan, Minutolo, Antonella, Grelli, Sandro, Federici, Giorgio, Bernardini, Sergio
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002728/
https://ncbi.nlm.nih.gov/pubmed/21927014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.107
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