Hepatitis B virus X protein suppresses virus-triggered IRF3 activation and IFN-β induction by disrupting the VISA-associated complex

Viral RNAs produced during viral infection are recognized by the cytoplasmic RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). A central adapter protein downstream of RIG-I and MDA5 is the mitochondrial membrane protein virus-induced signalin...

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Bibliografiske detaljer
Main Authors: Wang, Xianmiao, Li, Ying, Mao, Aiping, Li, Chao, Li, Yongkui, Tien, Po
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002683/
https://ncbi.nlm.nih.gov/pubmed/20711230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2010.36
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