WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-κB activation

Viral infection causes activation of the transcription factors NF-κB and IRF3, which collaborate to induce type I interferons (IFNs) and cellular antiviral response. The mitochondrial outer membrane protein VISA acts as a critical adapter for assembling a virus-induced complex that signals NF-κB and...

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Detalhes bibliográficos
Main Authors: Wang, Yan-Yi, Liu, Li-Juan, Zhong, Bo, Liu, Tian-Tian, Li, Ying, Yang, Yan, Ran, Yong, Li, Shu, Tien, Po, Shu, Hong-Bing
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818949/
https://ncbi.nlm.nih.gov/pubmed/20080758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908967107
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