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Aurora-A is a determinant of tamoxifen sensitivity through phosphorylation of ERα in breast cancer
Despite the clinical success of tamoxifen, its resistance remains a major challenge in breast cancer. Here we show that Aurora-A determines tamoxifen sensitivity by regulation of estrogen receptor (ER)α. Ectopic expression of Aurora-A decreases and depletion of Aurora-A enhances tamoxifen sensitivit...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4002670/ https://ncbi.nlm.nih.gov/pubmed/24166501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.444 |
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