Aurora-A is a determinant of tamoxifen sensitivity through phosphorylation of ERα in breast cancer

Despite the clinical success of tamoxifen, its resistance remains a major challenge in breast cancer. Here we show that Aurora-A determines tamoxifen sensitivity by regulation of estrogen receptor (ER)α. Ectopic expression of Aurora-A decreases and depletion of Aurora-A enhances tamoxifen sensitivit...

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Autors principals: Zheng, XQ, Guo, JP, Yang, H, Kanai, M, He, LL, Li, YY, Koomen, JM., Minton, S., Gao, M, Ren, XB, Coppola, D, Cheng, JQ
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002670/
https://ncbi.nlm.nih.gov/pubmed/24166501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.444
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