MuRF-1 and Atrogin-1 Protein Expression and Quadriceps Fiber Size and Muscle Mass in Stable Patients with COPD

INTRODUCTION: Animal studies demonstrate the importance of the E3 ubiquitin ligases, Muscle RING-Finger Protein 1 (MuRF-1) and atrogin-1, in muscle protein degradation during acute muscle atrophy. Small clinical studies suggest MuRF-1 and atrogin-1 expression in the quadriceps muscle is also increas...

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Detalhes bibliográficos
Main Authors: Natanek, Samantha A., Riddoch-Contreras, Joanna, Marsh, Gemma S., Hopkinson, Nicholas S., Moxham, John, Man, William D.-C., Kemp, Paul R., Polkey, Michael I.
Formato: Artigo
Idioma:Inglês
Publicado em: Informa Healthcare 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002632/
https://ncbi.nlm.nih.gov/pubmed/23844868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/15412555.2013.781577
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