Cytomegalovirus pp65 limits dissemination but is dispensable for persistence

The most abundantly produced virion protein in human cytomegalovirus (HCMV) is the immunodominant phosphoprotein 65 (pp65), which is frequently included in CMV vaccines. Although it is nonessential for in vitro CMV growth, pp65 displays immunomodulatory functions that support a potential role in pri...

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Autores principales: Malouli, Daniel, Hansen, Scott G., Nakayasu, Ernesto S., Marshall, Emily E., Hughes, Colette M., Ventura, Abigail B., Gilbride, Roxanne M., Lewis, Matthew S., Xu, Guangwu, Kreklywich, Craig, Whizin, Nathan, Fischer, Miranda, Legasse, Alfred W., Viswanathan, Kasinath, Siess, Don, Camp, David G., Axthelm, Michael K., Kahl, Christoph, DeFilippis, Victor R., Smith, Richard D., Streblow, Daniel N., Picker, Louis J., Früh, Klaus
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002596/
https://ncbi.nlm.nih.gov/pubmed/24691437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67420
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