Design, synthesis and biological evaluation of bivalent ligands against A(1)–D(1) receptor heteromers

AIM: To design and synthesize bivalent ligands for adenosine A(1)–dopamine D(1) receptor heteromers (A(1)–D(1)R), and evaluate their pharmacological activities. METHODS: Bivalent ligands and their corresponding A(1)R monovalent ligands were designed and synthesized. The affinities of the bivalent li...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Shen, Jian, Zhang, Lei, Song, Wan-ling, Meng, Tao, Wang, Xin, Chen, Lin, Feng, Lin-yin, Xu, Ye-chun, Shen, Jing-kang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
Schlagworte:
Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002486/
https://ncbi.nlm.nih.gov/pubmed/23334237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.151
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