SAHA, an HDAC inhibitor, synergizes with tacrolimus to prevent murine cardiac allograft rejection

Suberoylanilide hydroxamic acid (SAHA), as a histone deacetylase (HDAC) inhibitor (HDACi), was recently found to exhibit an immunosuppressive effect. However, whether SAHA can synergize with calcineurin inhibitors (CNIs) to inhibit allograft rejection and its underlying mechanism remain elusive. In...

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Hlavní autoři: Zhang, Xin, Han, Shu, Kang, Yindong, Guo, Meng, Hong, Shanjuan, Liu, Fang, Fu, Shangxi, Wang, Liming, Wang, Quan-Xing
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002334/
https://ncbi.nlm.nih.gov/pubmed/22922441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2012.28
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