SAHA, an HDAC inhibitor, synergizes with tacrolimus to prevent murine cardiac allograft rejection

Suberoylanilide hydroxamic acid (SAHA), as a histone deacetylase (HDAC) inhibitor (HDACi), was recently found to exhibit an immunosuppressive effect. However, whether SAHA can synergize with calcineurin inhibitors (CNIs) to inhibit allograft rejection and its underlying mechanism remain elusive. In...

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מידע ביבליוגרפי
Main Authors: Zhang, Xin, Han, Shu, Kang, Yindong, Guo, Meng, Hong, Shanjuan, Liu, Fang, Fu, Shangxi, Wang, Liming, Wang, Quan-Xing
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2012
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002334/
https://ncbi.nlm.nih.gov/pubmed/22922441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2012.28
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