SAHA, an HDAC inhibitor, synergizes with tacrolimus to prevent murine cardiac allograft rejection

Suberoylanilide hydroxamic acid (SAHA), as a histone deacetylase (HDAC) inhibitor (HDACi), was recently found to exhibit an immunosuppressive effect. However, whether SAHA can synergize with calcineurin inhibitors (CNIs) to inhibit allograft rejection and its underlying mechanism remain elusive. In...

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Detalhes bibliográficos
Main Authors: Zhang, Xin, Han, Shu, Kang, Yindong, Guo, Meng, Hong, Shanjuan, Liu, Fang, Fu, Shangxi, Wang, Liming, Wang, Quan-Xing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002334/
https://ncbi.nlm.nih.gov/pubmed/22922441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2012.28
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