SAHA, an HDAC inhibitor, synergizes with tacrolimus to prevent murine cardiac allograft rejection

Suberoylanilide hydroxamic acid (SAHA), as a histone deacetylase (HDAC) inhibitor (HDACi), was recently found to exhibit an immunosuppressive effect. However, whether SAHA can synergize with calcineurin inhibitors (CNIs) to inhibit allograft rejection and its underlying mechanism remain elusive. In...

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Bibliografiske detaljer
Main Authors: Zhang, Xin, Han, Shu, Kang, Yindong, Guo, Meng, Hong, Shanjuan, Liu, Fang, Fu, Shangxi, Wang, Liming, Wang, Quan-Xing
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002334/
https://ncbi.nlm.nih.gov/pubmed/22922441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2012.28
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