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T-type Channels Become Highly Permeable to Sodium Ions Using an Alternative Extracellular Turret Region (S5-P) Outside the Selectivity Filter

T-type (Ca(v)3) channels are categorized as calcium channels, but invertebrate ones can be highly sodium-selective channels. We illustrate that the snail LCa(v)3 T-type channel becomes highly sodium-permeable through exon splicing of an extracellular turret and descending helix in domain II of the f...

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Hlavní autoři: Senatore, Adriano, Guan, Wendy, Boone, Adrienne N., Spafford, J. David
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002102/
https://ncbi.nlm.nih.gov/pubmed/24596098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.551473
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