Anti-amyloid Compounds Inhibit α-Synuclein Aggregation Induced by Protein Misfolding Cyclic Amplification (PMCA)

Filaments made of α-synuclein form the characteristic Lewy pathology in Parkinson and other diseases. The formation of α-synuclein filaments can be reproduced in vitro by incubation of recombinant protein, but the filament growth is very slow and highly variable and so unsuitable for fast high throu...

Full description

Saved in:
Bibliographic Details
Main Authors: Herva, Maria Eugenia, Zibaee, Shahin, Fraser, Graham, Barker, Roger A., Goedert, Michel, Spillantini, Maria Grazia
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002097/
https://ncbi.nlm.nih.gov/pubmed/24584936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.542340
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items